Browse evidence-based analysis of health-related claims and assertions
Obese mice treated with MOTS-c had lower levels of ANGPTL4 in their muscles, which may help prevent fat buildup.
MOTS-c treatment in obese mice reduced the activity of a liver enzyme called Por by half, which may affect fat metabolism.
MOTS-c injections in obese mice lowered sebacate, a dicarboxylic acid, by 42% compared to untreated mice.
Obese mice given MOTS-c had lower levels of suberate, a dicarboxylic acid, by 40% compared to untreated mice.
MOTS-c injections in obese mice reduced a type of fat molecule called 2-oleoylglycerol by about 32% compared to untreated mice.
Obese mice treated with MOTS-c had lower levels of a specific sphingolipid called palmitoyl sphingomyelin, which is associated with insulin resistance.
MOTS-c injections in obese mice lowered a specific blood fat molecule called sphingosine 1-phosphate by about 14% compared to untreated mice.
Obese mice given MOTS-c injections for three days had lower blood sugar levels than mice that didn't receive the treatment.
When PGC-1α is increased in muscle cells, they break down a specific type of fat (lignoceric acid) more efficiently using both peroxisomes and mitochondria. This finding is from the abstract summary - full study details were not available
Increasing PGC-1α in muscle cells leads to higher levels of mRNA for breaking down fats in peroxisomes. This finding is from the abstract summary - full study details were not available
When muscle cells in a lab have more PGC-1α protein, they show higher levels of PMP70, which is a protein involved in peroxisome function. This finding is from the abstract summary - full study details were not available
In immobilized mice, higher levels of MOTS-c in the muscles were linked to better muscle mass retention.
MOTS-c lowered levels of myostatin, a protein that inhibits muscle growth, in the muscles of immobilized mice.
MOTS-c reduced the amount of fatty acids in the muscles of immobilized mice, which may prevent harmful fat buildup.
MOTS-c increased the production of a protein called ANGPTL4 in the muscles of immobilized mice, which helps control fat uptake into muscle tissue.
MOTS-c changed the activity of genes related to fat metabolism and PPAR pathways in the muscles of immobilized mice, which may affect how fat builds up in muscle tissue.
MOTS-c reduced levels of several inflammatory proteins in the blood of immobilized mice, which may help reduce muscle damage.
MOTS-c helped maintain higher activity levels of key muscle signaling proteins (AKT, FOXO1, FOXO3a) in immobilized mice, which are important for muscle health.
When mice had their legs immobilized for 8 days, giving them MOTS-c helped their muscles lose less weight (5% instead of 15%) compared to mice that didn't get the treatment.
For people with uncomplicated type 2 diabetes, sufficient oxygen in their muscles is linked to better energy recovery after exercise.
Higher blood sugar levels in obese adults with type 2 diabetes are linked to how well their muscles produce energy during exercise recovery.
Extra oxygen helps obese adults with type 2 diabetes produce muscle energy more quickly after exercise, as measured by oxidative phosphorylation rates.
Giving extra oxygen to obese adults with type 2 diabetes helps their muscles recover energy faster after exercise, as measured by quicker ADP depletion.
Obese adults with type 2 diabetes have slower muscle energy production rates after exercise compared to those without diabetes, as measured by oxidative phosphorylation.