Browse evidence-based analysis of health-related claims and assertions
In mice on a high-fat diet, a drug called GW501516 might boost a specific fat in the liver that could help turn on a fat-burning switch, making the body burn fat more efficiently.
In mice eating a high-fat diet, taking a drug called GW501516 seems to boost a substance in their blood that shows their liver is burning more fat for energy.
In mice eating a fatty diet, a drug called GW501516 seems to turn on a chain reaction in the liver that helps burn fat more efficiently.
In mice on a high-fat diet, a drug called GW501516 might help liver cells better manage fat by turning up a key protein and activating a fat-burning switch.
In mice eating a bad diet, a drug called GW501516 might help keep a key energy-sensing switch in the liver working properly, which could help their bodies handle the stress of unhealthy eating.
If mice eat a greasy, high-fat diet for a long time—like 20 weeks—they start building up fat in their livers, gain weight, and show signs of a condition similar to fatty liver disease in people.
When human liver cells are stressed by certain fats, blocking a specific protein (ACACA) seems to help reduce harmful stress chemicals and boost natural antioxidants, which might protect the cells.
When liver cells are exposed to certain fats—like in a high-fat diet—this study says a gene called ACACA becomes more active, and this might trigger a chain reaction in the cell that affects metabolism. It suggests blocking ACACA could help control these changes.
Blocking a certain enzyme (ACACA) seems to help liver cells and mice on a bad diet keep their energy factories (mitochondria) working better.
When liver cells in mice and humans are overloaded with fat, blocking a protein called ACACA helps reduce fat buildup, especially triglycerides and cholesterol, suggesting it plays a key role in how the liver handles excess fat.
In dairy cows, a substance made by gut microbes (acetic acid) might affect milk fat by turning on certain cellular switches (mTORC1 and AMPK) that control fat-related genes.
Acetic acid might help control how dairy cows make fat in their milk by turning certain genes on or off, depending on how much and how long they're exposed to it.
In dairy cows, vitamin B6 goes up in the stomach at night, and this might help move more acetic acid into the blood by turning on a protein called MCT1.
When certain gut bacteria in cows are more active at night, it might help them make milk with more fat — kind of like how our body uses food differently depending on the time of day.
Cows might make fattier milk at night because their gut bacteria and body chemicals change with the time of day.
If elite male cyclists eat a super high-fat diet for six days and then carb-load for one day, they’ll perform worse in sprints—even though they don’t feel more tired, their heart rate doesn’t change, and their muscles fire the same way.
If male cyclists eat a super high-fat diet for six days, their body's 'fight or flight' system might get a bit more active — and that change doesn’t go away right after they start eating carbs again.
If a male cyclist eats a super high-fat diet for 6 days and then loads up on carbs for 1 day, it won’t slow them down in a 100-km race compared to eating lots of carbs all along.
If elite male cyclists eat a super high-fat diet for six days, their bodies get better at burning fat for fuel — even when they switch back to eating lots of carbs for a day.
If elite male cyclists eat a super high-fat diet for 6 days before carb-loading for a day, they’ll feel just as fast over a long 100-km ride — but they’ll have less power for short, intense sprints compared to when they eat a high-carb diet first.
Elite race walkers who follow a keto diet for 3 weeks start burning fat for fuel during intense exercise, and their bodies show signs of ketosis — like having 1 mmol/L of ketones in the blood — even when working hard.
Elite race walkers who eat lots of carbs or time their carb intake during intense training get about 5-6% faster in a 10 km race, but those on a keto diet don’t get any faster.
Even if elite race walkers don't change their diet, their stamina can still improve after a few weeks of intense training, as long as they're eating enough calories.
Even though elite race walkers get better at using oxygen overall on a keto diet, the diet makes their bodies use more oxygen during race pace, so their performance doesn’t actually improve after 3 weeks.