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When myokines like IL-6 are constantly elevated due to inactivity or obesity, the body’s tissues become less responsive to the beneficial signals released during exercise, making it harder to improve...
During exercise, skeletal muscle releases signaling molecules like IL-6, FGF21, and GDF15 that influence metabolism, immune function, and appetite in other organs, but it is not yet proven that these...
After one intense workout, levels of certain inflammation-related proteins in the blood changed, and these changes were linked to how much vitamin D a woman had in her body. This finding is from the...
Women's vitamin D levels appear to be linked to how their inflammation markers and memory change after a single intense workout. This finding is from the abstract summary - full study details were...
After one intense workout using only body weight, young women showed better focus and spatial memory, while middle-aged women showed the opposite effect. This finding is from the abstract summary -...
In older adults with mild cognitive impairment, a smaller rise in BDNF after a short walk is linked to worse scores on memory and attention tests, even after accounting for age and walking distance....
Older adults with mild cognitive impairment have a smaller rise in two specific muscle-derived proteins—FABP-3 and osteocrin—after a short walk than those without cognitive impairment, even when...
Older adults with mild cognitive impairment show a smaller rise in brain-derived neurotrophic factor (BDNF) after a short walk than those without cognitive impairment, even when accounting for how...
After 20 days of intense interval training, the baseline level of interleukin-6 gene activity in muscle doesn't change, even though the same workout causes a stronger gene response afterward,...
In people who haven't trained recently, a single intense workout doesn't raise FNDC5 gene levels in muscle, but after 20 days of intense training, the same workout does increase it, showing the...
After 20 days of intense interval training, the baseline levels of the METRNL gene in muscle rise significantly, suggesting the muscle adapts to repeated high-intensity exercise by increasing this...
After 20 days of intense interval training, the baseline levels of the FNDC5 gene in muscle rise significantly, indicating the muscle adapts to repeated high-intensity exercise by increasing this...
After a short, intense workout, the levels of two specific muscle genes—interleukin-6 and METRNL—rise significantly within three hours, indicating the muscle is responding to the physical stress by...
Tiny particles from fat tissue in obese people trigger different molecular signals in two types of breast cancer cells: they activate a growth pathway in one type and a movement pathway in the other,...
Fluids secreted by fat tissue from obese people can make aggressive breast cancer cells signal to nearby blood vessel cells to form more tubes, which may help tumors grow their own blood supply.
Tiny particles released by fat tissue in obese people carry significantly more of the hormone leptin and a tissue-damaging enzyme called MMP9 than those from lean individuals, which may help explain...
Tiny particles from fat tissue in obese individuals can make aggressive breast cancer cells move faster and invade surrounding tissues in lab settings, by activating a specific signaling pathway that...
Tiny particles released by fat tissue from obese people can make certain types of breast cancer cells multiply faster in laboratory conditions by activating a specific cellular signaling pathway...
People with obesity have lower levels of a muscle-derived signaling molecule called IL-15 in their blood than people with normal weight, which may help explain why they are less active and more prone...
When the signal from IL-15 is blocked in the brain’s movement control center in mice, they become less active and lose the metabolic benefits they had from having p38α removed from their muscles.
When mice are given a gene that makes their muscles produce more of the active p38γ protein, they release more IL-15 into the blood, move around more, gain less weight on a fatty diet, and can run...
When the p38α protein is removed from mouse muscles, another protein called p38γ becomes more active, leading to more IL-15 being released into the blood, which makes the mice move more, gain less...
When people exercise, a specific protein called p38γ becomes active in their muscles, and this is linked to higher levels of a signaling molecule called IL-15 in the blood, which may help explain why...
Fat-derived particles from obese individuals increase the activity of an enzyme that breaks down tissue barriers in breast cancer cells, allowing them to spread, and this increase depends on leptin...