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Between 2001 and 2020, rare tumors called neuroendocrine tumors in the colon and rectum became more common each year at a faster rate than the more common type of colorectal cancer called...
Between 2001 and 2020, the number of new cases of colorectal cancer in adults aged 20 to 54 rose in every region of the United States, with the fastest increase in the West and the slowest in the...
Exposure to certain bacteria that produce DNA-damaging substances in early childhood may lead to genetic changes in the colon that can eventually result in colorectal cancer many years later.
Among people aged 35–39, the number of colorectal cancer cases rose faster in women (51%) than in men (44%) between 1990 and 2021, indicating that biological or lifestyle factors may affect women...
In the United States, the number of colorectal cancer cases in people under 50 increased by 49% between 1990 and 2021, from about 6,256 to 9,311 cases, indicating a growing trend in this age group.
From 1990 to 2021, the number of colorectal cancer cases in people aged 40 to 44 rose by 59%, and the rate adjusted for population age increased by 37%, showing that this age group experienced the...
People born in the United States after 1983, especially around 1996, are more likely to develop colorectal cancer at a young age than people born before them. This pattern suggests that factors...
Between 1990 and 2021, the number of new cases of colorectal cancer in people under age 45 in the United States rose by 34%, from 32.9 to 43.9 cases per 100,000 people.
A genetically modified strain of E. coli bacteria, designed to display a specific protein, reduces signs of intestinal damage and inflammation in mice with chemically induced colitis, as shown by...
Engineered bacteria with ClbS protein on their surface reduce DNA damage caused by a bacterial toxin in human colon tissue models and colorectal cancer cells.
A genetically modified strain of E. coli, designed to produce a protein that neutralizes colibactin, significantly lowers the levels of a harmful E. coli strain in the intestines of mice.
A genetically modified strain of E. coli bacteria, designed to produce a specific protein, reduces tumor formation by half to two-thirds in mice with intestinal inflammation and a genetic...
Engineered bacteria displaying a specific protein called ClbS can reduce DNA damage caused by a toxin produced by other bacteria, with higher levels of the protein nearly eliminating the damage in...
Patients with advanced colorectal cancer who were more physically active before surgery had fewer complications after surgery, regardless of whether the complications were mild or severe.
Patients with advanced colorectal cancer who were more physically active before surgery tended to leave the hospital sooner than those who were less active, based on average hospital stay durations.
Patients with advanced colorectal cancer who were more physically active before surgery had lower rates of certain complications after surgery, such as infections, breathing problems, and bowel...
Among patients with advanced colorectal cancer who undergo surgery to relieve symptoms, those who were physically active before surgery (at least 12 MET hours per week) did not live longer than those...
Patients with advanced colorectal cancer who engaged in at least 12 MET hours of weekly physical activity before surgery had lower rates of complications and death after surgery compared to those who...
People who engage in less than 600 MET-minutes of physical activity per week may not receive the protective benefit against colorectal cancer that higher activity levels provide, even if they reduce...
People who sit for long periods and are not physically active may have a higher risk of colorectal cancer, and this risk appears to be even higher for Black and Asian individuals compared to others.
People who engage in at least 2000 MET-minutes of physical activity per week and sit less than four hours per day have a lower risk of developing colorectal cancer compared to those who are less...
Adults who sit for more than 8 hours a day but engage in at least 2000 MET-minutes of physical activity per week have a significantly lower risk of developing colorectal cancer compared to those who...
Adults who are not physically active and sit for more than 8 hours a day have a higher risk of developing colorectal cancer, with the risk being higher in U.S. populations than in Korean populations.
Colorectal cancers with colibactin-related DNA damage patterns show the same levels of overall mutations and known cancer-causing gene changes as other colorectal cancers, suggesting colibactin...