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Over the course of a two-year, placebo-controlled, double-blinded clinical trial, researchers found that high-dose omega-3 supplements failed to improve memory, cognitive performance, or brain cell loss in regions associated with Alzheimer's. 2 years?

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Fit Body Science
Science fact-checking · Jul 29, 2026

The DHA in omega-3 supplements may not help, but EPA—another omega-3—combined with antioxidants actually improved memory and thinking in Alzheimer's patients. Plus, fish oil benefited people without the APOE4 gene. https://s.fitbodyscience.com/9kXLZz

Every claim checked against peer-reviewed researchSee the full breakdown
Scientific verdict1 claim checked

There's disagreement

Studies point in different directions — there's no clear consensus yet.

80Supports
67Challenges
The breakdown

A two-year trial found no cognitive boost from omega-3 supplements, but other research hints at benefits for specific groups.

The study linked in the post indeed found no benefit from omega-3 supplements on cognitive function over two years. However, other research tells a more nuanced story: one study found that fish oil pills helped memory and brain health in people without a certain genetic risk factor (APOE4), while another large analysis showed slight improvements on a thinking test overall. Additionally, a study using a specific type of omega-3 (EPA) combined with antioxidants actually improved memory and thinking in people with Alzheimer's. So while the big trial says supplements alone don't seem to work, some evidence suggests they might help certain people or when used differently.

Bottom line

So if you're popping omega-3 pills hoping to sharpen your memory, this trial suggests you're probably wasting your money—but don't count them out entirely, because other studies show they might still benefit some folks under the right conditions.

ReliabilityThe evidence is mixed — some research supports it, some contradicts it.
Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.