Research Database

To determine whether creatine functions as a compatible osmolyte in muscle cells under hypertonic stress by assessing its transporter regulation and protective...

To determine whether creatine supplementation increases muscle mass by altering muscle protein synthesis or breakdown at rest.

To determine the mechanism by which insulin activates the Na⁺/K⁺-ATPase in rat skeletal muscle.

To determine the mechanism by which insulin stimulates (Na+,K+)-ATPase transport activity in muscle cells.

To characterize the kinetics and mechanisms of creatine uptake in isolated rat soleus muscle, particularly regarding sodium dependence and insulin effects.

Assess the effects of creatine supplementation on inflammatory biomarkers in humans across populations and protocols.

To review how insulin regulates Na+/K+-ATPase structure, function, and metabolism across tissues and assess therapeutic potential.

To determine if carbohydrate ingestion enhances creatine retention and whether exercise prior to ingestion further increases retention in healthy adult males.

To determine whether short-term creatine monohydrate supplementation affects protein metabolism during resistance training in young healthy men and women.