Do super fatty diets change your blood proteins?
A high intake of industrial or ruminant trans fatty acids does not affect the plasma proteome in healthy men
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Even at 7% of daily calories—far above normal intake—industrial trans fats and CLA did not significantly alter the plasma proteome.
Most people assume trans fats wreak havoc at the molecular level; this study shows no detectable protein-level changes, contradicting assumptions about their mechanism.
Practical Takeaways
Don’t assume that if a food doesn’t change blood proteins, it’s safe—trans fats are still linked to heart disease through other known pathways.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Even at 7% of daily calories—far above normal intake—industrial trans fats and CLA did not significantly alter the plasma proteome.
Most people assume trans fats wreak havoc at the molecular level; this study shows no detectable protein-level changes, contradicting assumptions about their mechanism.
Practical Takeaways
Don’t assume that if a food doesn’t change blood proteins, it’s safe—trans fats are still linked to heart disease through other known pathways.
Publication
Journal
PROTEOMICS
Year
2011
Authors
B. de Roos, A. Wanders, S. Wood, G. Horgan, Garry Rucklige, M. Reid, E. Siebelink, I. Brouwer
Related Content
Claims (4)
Dietary intake of industrial trans fatty acids, even at low levels, is causally associated with increased risk of cardiovascular disease, stroke, and type 2 diabetes.
Even when people ate a lot of artificial trans fats—way more than normal—their blood proteins didn’t change much, so these fats might not mess with the body’s protein signals in a big way.
Even when people ate a very high amount of trans fats—either artificial or from dairy—their blood proteins didn’t change enough to be picked up by the method used, meaning this way of studying proteins might not be good for spotting diet effects.
Even when people ate a lot of a specific trans fat found in dairy (CLA), their blood proteins stayed pretty much the same, so this type of fat probably doesn’t change how the body uses proteins in the blood.