The Study
The antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation.
This study only looked at fat cells in a dish, not real people, and we don’t know how they picked the cells or what they compared them to. So we can’t say anything for sure about how insulin works in real bodies with obesity or diabetes.
Analysis score
Maximum 44 for a cross-sectional study.
Where the score came from
Insulin usually tells fat cells to stop breaking down fat, but in people with obesity or diabetes, this doesn't seem to be why their bodies can't use insulin properly.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 520 / 100
Quality score
Snapshots of a population at a single point in time, or descriptions of small groups. Can identify correlations and prevalence, but cannot determine cause and effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1This suggests that fixing fat breakdown won't fix insulin resistance in these conditions.
- 2Not specified
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Metabolism: clinical and experimental
Year
1981
Authors
P. Arner, J. Bolinder, P. Engfeldt, J. Östman
Related Content
Claims (2)
When cells become resistant to insulin, fat breakdown decreases, leading to less fatty acid release into the blood and more fat accumulation in the liver.
In people with obesity, diabetes, high insulin levels, or starvation, the failure of insulin to stop fat breakdown in fat tissue does not cause insulin resistance.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.