A new weight-loss shot helps people lose a lot of weight and feel better
Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: A systematic review and meta-analysis of randomized controlled trials
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Retatrutide increased the likelihood of losing 20% or more of body weight by 16.6 times compared to placebo — even higher than the 15% threshold.
Most weight-loss drugs rarely push people past 10–15% loss; hitting 20% is usually only seen with bariatric surgery. This drug is approaching surgical-level results without surgery.
Practical Takeaways
If you have obesity or type 2 diabetes, ask your doctor if you’re a candidate for upcoming retatrutide trials — it may be your best shot at major weight loss without surgery.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Retatrutide increased the likelihood of losing 20% or more of body weight by 16.6 times compared to placebo — even higher than the 15% threshold.
Most weight-loss drugs rarely push people past 10–15% loss; hitting 20% is usually only seen with bariatric surgery. This drug is approaching surgical-level results without surgery.
Practical Takeaways
If you have obesity or type 2 diabetes, ask your doctor if you’re a candidate for upcoming retatrutide trials — it may be your best shot at major weight loss without surgery.
Publication
Journal
Metabolism Open
Year
2024
Authors
E. Pasqualotto, R. Ferreira, M. Chavez, Alexandre Hohl, M. Ronsoni, Tales Pasqualotto, F. A. Moraes, L. Hespanhol, Janine Midori Figueiredo Watanabe, Carine Lütkemeyer, Simone van de Sande-Lee
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Claims (6)
When people take medicine to lose weight, their body inflammation goes down and their metabolism gets better, which helps lower their chance of heart problems.
Taking a weekly shot of retatrutide might make you feel more nauseous, throw up, get constipated, or have allergic reactions than if you took a fake shot — but these side effects aren’t life-threatening and are kind of expected.
Taking a weekly injection called retatrutide might help people who are overweight or have type 2 diabetes lose around 10-11 pounds, shrink their waistline, and lower their BMI — which could mean real, helpful weight loss.
People who get a weekly shot of a new medicine called retatrutide are about 18 times more likely to lose at least 15% of their body weight than those who get a placebo, which could mean a lot of them reach a weight loss level that really improves their health.
A once-a-week shot called retatrutide may help lower blood sugar levels in people who are overweight, obese, or have type 2 diabetes—even if they don’t lose weight.