How a pollutant gives mice fatty liver
BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPARα-induced abnormal fatty acid oxidation in BALB/c mice.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Publication
Journal
Toxicology letters
Year
2023
Authors
Beibei Xia, R. Yu, Junxiong Liu, Dongmeng Liu, Shasha Li, Liu Yang, Nan Liu, Bosen Liang, J. Zeng, Jinhua Wei, Guimiao Lin
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Claims (3)
In these lab mice, a chemical called BDE-47 turns up a protein that pulls more fat into the liver, which can lead to fatty liver disease.
In mice, being exposed to a chemical called BDE-47 might cause their livers to store more fat and not burn it properly, leading to fatty liver and signs of liver damage — a possible early sign of a liver disease linked to metabolism problems.
When these lab mice are exposed to a chemical called BDE-47, it might slow down their liver's ability to burn fat, leading to fat buildup that could cause a type of liver disease.