The Study
Investigation of possible underlying mechanisms behind water-induced glucose reduction in adults with high copeptin
This study watched what happened when people drank more water for six weeks, and noticed that some of their body chemicals changed at the same time. But because there was no group that didn’t drink extra water to compare to, we can’t say the water caused the changes — maybe they just happened on their own.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
If you don't drink enough water and your body shows signs of being very dry inside (high copeptin), drinking an extra 1.5 liters of water a day for six weeks can help lower your blood sugar.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 553 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — this could mean drinking more water is a simple, low-risk way to help manage blood sugar for people who are chronically dehydrated and at risk for diabetes.
- 2People with the highest dehydration levels saw their blood sugar drop and their stress hormone (ACTH) drop by nearly half — from 13.0 to 7.7 pmol/L.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Scientific Reports
Year
2021
Authors
S. Enhörning, Tiphaine Vanhaecke, A. Dolci, Erica T. Perrier, O. Melander
Related Content
Claims (6)
In adults with high initial levels of copeptin, a decrease in copeptin after six weeks of drinking more water is associated with a decrease in ACTH, especially in those with the highest starting copeptin levels.
Among adults with elevated copeptin, drinking more water for six weeks leads to simultaneous decreases in blood glucose and cortisol levels.
Among adults with the highest initial levels of copeptin, drinking more water is linked to the largest decreases in copeptin and glucose levels.
Drinking an extra 1.5 liters of water each day for six weeks lowers fasting blood glucose levels in people who are moderately dehydrated.
Adults with high copeptin levels and low water intake who drink an extra 1.5 liters of water per day for six weeks have lower fasting blood glucose and lower fasting copeptin levels.
Among adults with high initial copeptin levels, a decrease in copeptin after drinking more water for six weeks is linked to a decrease in glucagon, but this link does not occur in those whose glucose levels drop the most.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.