Does a cholesterol drug help prevent heart problems in high-risk people who haven’t had a heart attack or stroke?
Evolocumab in Patients without a Previous Myocardial Infarction or Stroke.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A drug called evolocumab was tested in people with diabetes or artery disease but no prior heart attack or stroke. It helped prevent heart attacks, strokes, and heart-related deaths.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 595 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A drug called evolocumab was tested in people with diabetes or artery disease but no prior heart attack or stroke. It helped prevent heart attacks, strokes, and heart-related deaths.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 595 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Bohula EA, Marston NA, Bhatia AK, De Ferrari GM, Leiter LA, Nicolau JC, Park JG, Kuder JF, Murphy SA, Walsh E, Wang H, Blaha V, Budaj A, Cornel JH, Goudev A, Kiss RG, Lorenzatti AJ, Parkhomenko A, Cyrille M, Paiva da Silva Lima G, Ohman EM, Giugliano RP, Sabatine MS, VESALIUS-CV Investigators
Related Content
Claims (4)
Taking a drug called evolocumab can lower the chance of having a first major heart problem by 25% in people at high risk who’ve never had a heart attack or stroke before.
For people at high risk for heart problems because of diabetes or clogged arteries, taking a drug called evolocumab every two weeks can lower their chances of having a heart attack, stroke, or needing heart surgery by about 1 in 5 over nearly 5 years, compared to those who don’t take it.
Taking a drug called evolocumab every two weeks is just as safe as taking a fake pill (placebo) for people with certain heart risks — there’s no real difference in side effects after nearly 5 years.
For people with diabetes or clogged arteries who haven’t had a heart attack or stroke yet, taking a drug called evolocumab every two weeks can lower their chance of having a first heart attack, stroke, or heart-related death by about 25% over nearly 5 years.