What happens to artificial sweetener in a rat's body?
Intestinal Metabolism and Bioaccumulation of Sucralose In Adipose Tissue In The Rat
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Two new acetylated metabolites of sucralose were detected, and sucralose persisted in adipose tissue for two weeks after dosing stopped.
Sucralose was long considered non-metabolized and non-bioaccumulative—this directly contradicts the basis for its regulatory approval.
Practical Takeaways
Consider reducing or monitoring intake of sucralose if you're concerned about long-term accumulation.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Two new acetylated metabolites of sucralose were detected, and sucralose persisted in adipose tissue for two weeks after dosing stopped.
Sucralose was long considered non-metabolized and non-bioaccumulative—this directly contradicts the basis for its regulatory approval.
Practical Takeaways
Consider reducing or monitoring intake of sucralose if you're concerned about long-term accumulation.
Publication
Journal
Journal of Toxicology and Environmental Health, Part A
Year
2018
Authors
V. Bornemann, S. Werness, L. Buslinger, S. Schiffman
Related Content
Claims (4)
Scientists test artificial sweeteners on animals using way more than humans would ever eat, then say it’s safe for people by dividing that huge dose by 100—but that doesn’t match how much people actually consume.
When rats eat sucralose every day for 40 days, their intestines turn it into two new substances that scientists didn’t know existed before—this means it’s not just passing through their bodies unchanged like we thought.
When rats are given sucralose, a sugar substitute, it sticks around in their fat tissue for at least two weeks after they stop taking it—even though it’s no longer showing up in their pee or poop.
After your body breaks down artificial sweetener sucralose, it makes two modified versions that stick to fat more easily — and that’s why they might hang around in your fat tissue longer than the original sweetener.