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Why citrulline beats arginine for making nitric oxide
Original Title
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
doi:10.1111/J.1365-2125.2007.02990.X66%
Moderate Quality
Methodology score · 66/100
Rct Human
Fit Body Science breakdown
We translate health research into clear, actionable insights. Here’s what this study found and what it means for you.
Not medical advice. For informational purposes only. Always consult a healthcare professional.
What’s the bottom line?
Your body makes nitric oxide from arginine, but eating arginine pills doesn't work well because your liver breaks them down too fast. Citrulline pills go straight to the liver and get turned into arginine instead — so more nitric oxide gets made.
Score breakdown, methodology, COI, evidence analysis & raw study data
Publication
Authors
Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger RH