Taking a specific amino acid supplement called L-citrulline twice a day for a week helps your body make more nitric oxide, which shows up as higher levels of certain chemicals in your urine.

66

Pro

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Against

Evidence from Studies

Supporting (1)

66

Community contributions welcome

66

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.

Randomized Controlled Trial

Human

2008 Jan

The study gave people 3 grams of L-citrulline twice a day for a week and found that their bodies produced 36% more nitrate and 32% more cGMP — both signs that their body made more nitric oxide, just like the claim said.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.

Score: 66

DOI: 10.1111/J.1365-2125.2007.02990.X

Similar Assertions

Taking a specific amino acid supplement called L-citrulline twice a day for a week helps the body make more nitric oxide, which shows up as higher levels of certain waste products in the urine — this suggests the body’s blood vessels might be working better.

66

0

92%

Taking a specific amino acid called L-citrulline twice a day for a week boosts a related chemical in your blood more than taking that chemical directly, which might help your body make more of a molecule that relaxes your blood vessels.

66

0

79%

Taking citrulline pills every day for a week at a specific dose doesn't help your body hold onto more protein, even if you're healthy and eating well.

47

0

77%

Taking a specific amount of citrulline powder every day for a week can raise levels of certain amino acids in your blood, but it doesn’t change other important blood or urine markers like insulin or albumin.

47

0

76%

Taking a specific amino acid supplement called L-citrulline twice a day for a week can help improve a key balance in your blood that lets your body make more nitric oxide — a molecule that helps your blood vessels relax and work better.

66

0

73%