Analysis Version
v1
History
Back to Study: Oral citrulline does not affect whole body protein...
quantitative
Analysis v1
47
Pro
0
Against

Taking citrulline pills every day for a week at a specific dose doesn't help your body hold onto more protein, even if you're healthy and eating well.

Claim Language

Language Strength

definitive

Uses definitive language (causes, prevents, cures)

The phrase 'does not improve' is a definitive statement because it asserts a clear, absolute absence of effect rather than suggesting possibility, likelihood, or association.

Context Details

Domain

nutrition

Population

human

Subject

Oral citrulline supplementation at 0.18 g/kg/day for 7 days

Action

does not improve

Target

nitrogen balance in healthy, well-nourished adults in the post-absorptive state

Intervention Details

Type: supplement
Dosage: 0.18 g/kg/day
Duration: 7 days

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Evidence from Studies

Supporting (1)

47
47

Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study.

Randomized Controlled Trial
Human
2011 Dec

Scientists gave healthy people a daily citrulline pill for a week and checked if their bodies held onto more protein — they didn’t. The pill raised some blood chemicals but didn’t help with protein balance.

Contradicting (0)

0
No contradicting evidence found

Source Study

Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study.

Score: 47
DOI: 10.1016/j.clnu.2011.06.005

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