Taking a specific amount of citrulline powder every day for a week can raise levels of certain amino acids in your blood, but it doesn’t change other important blood or urine markers like insulin or albumin.

47

Pro

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Against

Evidence from Studies

Supporting (1)

47

Community contributions welcome

47

Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study.

Randomized Controlled Trial

Human

2011 Dec

The study gave people citrulline pills for a week and found that it raised levels of citrulline, arginine, and ornithine in their blood — just like the claim said. It also confirmed that other things like insulin and albumin didn’t change, so the claim is correct.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study.

Score: 47

DOI: 10.1016/j.clnu.2011.06.005

Similar Assertions

Taking a specific amount of citrulline powder every day for a week makes certain amino acids go up in your blood, but it doesn’t change how your body builds or breaks down protein when you haven’t just eaten.

47

0

94%

Taking citrulline pills every day for a week at a specific dose doesn't help your body hold onto more protein, even if you're healthy and eating well.

47

0

83%

Taking a specific amino acid called L-citrulline twice a day for a week boosts a related chemical in your blood more than taking that chemical directly, which might help your body make more of a molecule that relaxes your blood vessels.

66

0

78%

Taking a specific amino acid supplement called L-citrulline twice a day for a week helps your body make more nitric oxide, which shows up as higher levels of certain chemicals in your urine.

66

0

76%

Taking a specific amino acid called L-citrulline twice a day for a week helps raise levels of another amino acid, L-arginine, in the blood more than taking L-arginine directly—this might help your body make more nitric oxide, which is good for blood flow.

66

0

76%