Taking a specific amino acid called L-citrulline twice a day for a week helps raise levels of another amino acid, L-arginine, in the blood more than taking L-arginine directly—this might help your...

From: Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.

Strongly supported

Multiple high-quality studies back this claim.

66
Pro
0
Against
causal
1 study

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What this claim means

Taking a specific amino acid called L-citrulline twice a day for a week helps raise levels of another amino acid, L-arginine, in the blood more than taking L-arginine directly—this might help your...

See the technical phrasing

Oral L-citrulline supplementation at a dose of 3 g twice daily for 7 days increases plasma L-arginine concentration more effectively than L-arginine supplementation in healthy adults with elevated asymmetric dimethylarginine (ADMA), resulting in an increase in the area under the curve (AUC) by 898 µmol·h/L and a trough concentration (Cmin) of 45 µmol/L, thereby enhancing substrate availability for nitric oxide synthesis.

What the research says

Supports

1 study

66

Study: Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.

This study provides evidence supporting the claim.

Contradicts

0 studies

0

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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