mechanistic
Analysis v1
Strong Support
Taking a specific amino acid supplement called L-citrulline twice a day for a week helps the body make more nitric oxide, which shows up as higher levels of certain waste products in the urine — this suggests the body’s blood vessels might be working better.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
Randomized Controlled Trial
Human
2008 JanThe study gave people L-citrulline pills twice a day for a week and found that their bodies made more nitric oxide, which showed up as higher levels of nitrate and cGMP in their urine — just like the claim said.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.