Losing weight on junk food doesn't fix fat tissue inflammation
Caloric restriction-induced weight loss with a high-fat diet does not fully recover visceral adipose tissue inflammation in previously obese C57BL/6 mice.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Mice got fat eating high-fat food, then lost weight either by eating less junk food or switching to healthy food. Both lost the same weight, but only the healthy-food group fully healed their fat tissue inflammation.
Surprising Findings
Caloric restriction on a high-fat diet reduced fat mass to match a low-fat diet but failed to normalize key inflammatory markers.
Most people assume weight loss = reduced inflammation, but this study shows the type of diet during weight loss can leave lasting inflammatory damage even after fat loss.
Practical Takeaways
If you're losing weight on a high-fat or low-carb diet, consider adding more vegetables, fiber, and omega-3s to help reduce lingering inflammation.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Mice got fat eating high-fat food, then lost weight either by eating less junk food or switching to healthy food. Both lost the same weight, but only the healthy-food group fully healed their fat tissue inflammation.
Surprising Findings
Caloric restriction on a high-fat diet reduced fat mass to match a low-fat diet but failed to normalize key inflammatory markers.
Most people assume weight loss = reduced inflammation, but this study shows the type of diet during weight loss can leave lasting inflammatory damage even after fat loss.
Practical Takeaways
If you're losing weight on a high-fat or low-carb diet, consider adding more vegetables, fiber, and omega-3s to help reduce lingering inflammation.
Publication
Journal
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Year
2020
Authors
M. O. Rodrigues, P. H. Evangelista-Silva, Nilma Nayara Neves, L. G. Moreno, C. S. Santos, K. L. S. Rocha, V. Ottone, Breno Batista-da-Silva, M. F. Dias-Peixoto, F. Magalhaes, E. Esteves
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Claims (4)
Improvements in metabolic markers and weight loss observed on extreme low-carb or carnivore diets are primarily attributable to caloric restriction and elimination of ultra-processed foods, not to the physiological properties of animal-based foods alone.
Even when obese mice lose weight by eating less on a high-fat diet, their belly fat stays inflamed — unlike mice that eat a healthy low-fat diet, whose inflammation goes away.
When obese mice lose weight by eating less on fatty food, their belly fat stays more inflamed than when they lose weight eating healthy food — even if they weigh the same.
When obese mice eat less on a high-fat diet, they lose belly fat and their fat cells shrink just as much as mice eating a low-fat diet — even if the high-fat group still has more inflammation.