When obese mice lose weight by eating less on fatty food, their belly fat stays more inflamed than when they lose weight eating healthy food — even if they weigh the same.

Even when obese mice lose weight by eating less on a high-fat diet, their belly fat stays inflamed — unlike mice that eat a healthy low-fat diet, whose inflammation goes away.

When obese mice eat less on a high-fat diet, they lose belly fat and their fat cells shrink just as much as mice eating a low-fat diet — even if the high-fat group still has more inflammation.

When overweight mice eat significantly less food, they lose body fat no matter if their diet is low in carbs, low in fat, or high in protein — the key is eating fewer calories overall.

When overweight mice lose weight by eating less, their cholesterol levels go down — no matter what kind of food they eat — because the drop in cholesterol is tied to how much weight they lost.

In mice on a high-fat diet, repeatedly losing and regaining weight through calorie restriction does not worsen key metabolic markers such as blood sugar, fat levels in the blood, or body fat compared to mice that maintain a stable weight.