Even when obese mice lose weight by eating less on a high-fat diet, their belly fat stays inflamed — unlike mice that eat a healthy low-fat diet, whose inflammation goes away.

When obese mice lose weight by eating less on fatty food, their belly fat stays more inflamed than when they lose weight eating healthy food — even if they weigh the same.

When obese mice eat less on a high-fat diet, they lose belly fat and their fat cells shrink just as much as mice eating a low-fat diet — even if the high-fat group still has more inflammation.

When overweight mice eat significantly less food, they lose body fat no matter if their diet is low in carbs, low in fat, or high in protein — the key is eating fewer calories overall.

In obese women between 20 and 45 years old, losing weight slowly over 15 weeks with a moderate calorie reduction leads to a larger decrease in two markers of systemic inflammation—interleukin-1 and high-sensitivity C-reactive protein—than losing weight quickly over 12 weeks with a larger calorie reduction.

In obese women between 20 and 45 years old, losing weight at a moderate pace through a 20–25% calorie reduction over 10 weeks leads to a 22.66% decrease in plasma interleukin-1 levels compared to rapid weight loss, but shows no significant difference compared to slow weight loss.