Can blocking one protein fix both cancer and lupus?
Abstract PR-06: Disrupting TACI signaling to restore immune balance: harnessing translational opportunities at the intersection of cancer and autoimmunity
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists blocked a protein called TACI in mice with leukemia or lupus and found it helped stop the bad immune behavior in both diseases without weakening the body’s ability to fight infections.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 527 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists blocked a protein called TACI in mice with leukemia or lupus and found it helped stop the bad immune behavior in both diseases without weakening the body’s ability to fight infections.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 527 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
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Claims (6)
When stressors and nutritional deficiencies are corrected in people with chronic autoimmune conditions, the body's internal balance returns to normal.
In mice with lupus and chronic lymphocytic leukemia, blocking TACI maintains antibody responses from vaccines and normal blood cell levels without causing widespread immune suppression.
In mice with a disease similar to lupus, removing the TACI gene lowers autoantibody levels, restores normal T follicular helper cell function, prevents kidney damage, and keeps plasma cell numbers stable without weakening overall immune function.
In mouse models, TACI signaling increases the movement of chronic lymphocytic leukemia cells to the spleen and promotes an immune-suppressing environment that allows the tumor to survive.
Blocking TACI signaling in mice with chronic lymphocytic leukemia reduces tumor size, returns IL-6 and IL-10 cytokine levels to normal, restores T-cell populations, and lowers PD-L1 and PD-L2 expression.