A new pill lowers bad cholesterol without side effects
Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Doctors tested a new medicine called atorvastatin on people with high cholesterol. They gave different doses to see how well it worked.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 557 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Doctors tested a new medicine called atorvastatin on people with high cholesterol. They gave different doses to see how well it worked.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 557 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Nawrocki JW, Weiss SR, Davidson MH, Sprecher DL, Schwartz SL, Lupien PJ, Jones PH, Haber HE, Black DM
Related Content
Claims (6)
The liver makes cholesterol using a key enzyme called HMG-CoA reductase, and if we block that enzyme, it lowers the 'bad' cholesterol in your blood.
Taking atorvastatin every day for 6 weeks can lower 'bad' cholesterol by up to 60% in people with high cholesterol, and the higher the dose, the more it drops.
Atorvastatin doesn’t just lower bad cholesterol — it also lowers overall cholesterol and a key protein linked to heart disease, and higher doses make these effects stronger.
Inhibition of hepatic HMG-CoA reductase reduces circulating LDL cholesterol by decreasing endogenous cholesterol synthesis and upregulating hepatic LDL receptor expression.
This new statin, atorvastatin, lowers bad cholesterol more than older statins have been shown to in past studies.