Where in the heart does the diabetes drug target exist?
GLP-1 Receptor Expression Within the Human Heart
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists looked for the target of diabetes and obesity drugs in the human heart to see if it's really there.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists looked for the target of diabetes and obesity drugs in the human heart to see if it's really there.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 544 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ
Related Content
Claims (6)
We know the heart has the genetic instructions for a certain protein (GLP-1R), but we can't yet tell which exact heart cells actually make it because our tools aren't sensitive enough to see it clearly.
Your body has special switches called GLP-1 receptors not just in your gut and pancreas, but also in your heart, brain, kidneys, and even cartilage — and they help control different body functions in all those places.
The heart has the same kind of genetic message for the GLP-1 receptor as the pancreas, which means the heart might respond to GLP-1 signals—even though we're not sure yet if that message actually turns into working proteins there.
The gene for the GLP-1 receptor isn't found in certain heart cells, so those cells probably aren't the main places where this receptor works in the human heart when things are normal.
Scientists found the genetic instructions for a certain receptor in the heart's natural pacemaker, which might mean that a hormone involved in blood sugar control could directly affect how fast your heart beats.