The Study
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test
This study is like watching 42 people who chose to take a vitamin supplement and comparing their biological age before and after. It found that most of them seemed younger after taking it. But here's the problem: there's no comparison group! We don't know if people who DON'T take the supplement would also seem younger over time, or if this is just the placebo effect (thinking you're doing something healthy makes you feel better). Because there's no control group, we can't say for sure that the supplement CAUSED the change - it could just be coincidence or other factors.
Analysis score
Maximum 72 for a cohort study.
Where the score came from
Researchers gave 42 adults a supplement called Rejuvant® (containing alpha-ketoglutarate and vitamins) for about 7 months. They measured biological age using a DNA methylation blood test before and after. Most people (95%) showed a reduction in biological age averaging 8 years.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 539 / 100
Quality score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes, potentially significant for humans if the effect is real and sustained.
- 2An 8-year reduction in biological age could theoretically delay age-related diseases.
- 3However, the test has a 4+ year error margin and there's no control group.
- 442 adults took Rejuvant® for 7 months.
- 5Average biological age reduced by 8 years.
- 640 out of 42 people (95%) showed reduced biological age.
- 7The test used has an error margin of about 4 years.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Aging (Albany NY)
Year
2021
Authors
Oleksandr Demidenko, Diogo Barardo, Valery Budovskii, Robb Finnemore, F. R. Palmer, B. Kennedy, Yelena Budovskaya
Related Content
Claims (6)
Thirteen people who didn't change anything about their lifestyle except taking a supplement called Rejuvant® for about 7 months saw their biological age drop by nearly 8 years on average.
People who looked older than their actual age (based on biological markers) saw bigger improvements in their biological age after taking Rejuvant® supplement, meaning the supplement might work better for people who are aging faster.
A study found that adults who took a supplement called Rejuvant® (containing alpha-ketoglutarate and vitamins) for about 7 months had their biological age reduced by an average of 8 years, as measured by a DNA test called TruAge.
A company studied their supplement Rejuvant® and found that 40 out of 42 people (almost everyone) became biologically younger after taking it for several months.
Taking Rejuvant® supplements for longer periods doesn't necessarily mean you'll get more benefits in terms of reducing your biological age - the effect seems to max out after about 7 months.
Men taking Rejuvant® for 4-10 months looked about 8.4 years younger biologically, while women looked about 7 years younger on average.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.