Can a supplement reduce your biological age?
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Researchers gave 42 adults a supplement called Rejuvant® (containing alpha-ketoglutarate and vitamins) for about 7 months. They measured biological age using a DNA methylation blood test before and after. Most people (95%) showed a reduction in biological age averaging 8 years.
Surprising Findings
Duration didn't matter—taking the supplement longer didn't lead to more reduction
Most supplements and drugs show dose-response relationships—more is usually better. Here, people taking it for 4 months saw similar effects to those taking it for 10 months, suggesting the effect might max out quickly around 7 months.
Practical Takeaways
Don't buy Rejuvant® expecting guaranteed anti-aging effects based on this study
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Researchers gave 42 adults a supplement called Rejuvant® (containing alpha-ketoglutarate and vitamins) for about 7 months. They measured biological age using a DNA methylation blood test before and after. Most people (95%) showed a reduction in biological age averaging 8 years.
Surprising Findings
Duration didn't matter—taking the supplement longer didn't lead to more reduction
Most supplements and drugs show dose-response relationships—more is usually better. Here, people taking it for 4 months saw similar effects to those taking it for 10 months, suggesting the effect might max out quickly around 7 months.
Practical Takeaways
Don't buy Rejuvant® expecting guaranteed anti-aging effects based on this study
Publication
Journal
Aging (Albany NY)
Year
2021
Authors
Oleksandr Demidenko, Diogo Barardo, Valery Budovskii, Robb Finnemore, F. R. Palmer, B. Kennedy, Yelena Budovskaya
Related Content
Claims (6)
Thirteen people who didn't change anything about their lifestyle except taking a supplement called Rejuvant® for about 7 months saw their biological age drop by nearly 8 years on average.
People who looked older than their actual age (based on biological markers) saw bigger improvements in their biological age after taking Rejuvant® supplement, meaning the supplement might work better for people who are aging faster.
A study found that adults who took a supplement called Rejuvant® (containing alpha-ketoglutarate and vitamins) for about 7 months had their biological age reduced by an average of 8 years, as measured by a DNA test called TruAge.
A company studied their supplement Rejuvant® and found that 40 out of 42 people (almost everyone) became biologically younger after taking it for several months.
Taking Rejuvant® supplements for longer periods doesn't necessarily mean you'll get more benefits in terms of reducing your biological age - the effect seems to max out after about 7 months.