Do leaky guts cause fatigue and pain?
Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists checked blood for signs of a leaky gut in people with fibromyalgia and ME/CFS and compared them to healthy people.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists checked blood for signs of a leaky gut in people with fibromyalgia and ME/CFS and compared them to healthy people.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 541 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Martín F, Blanco-Suárez M, Zambrano P, Cáceres O, Almirall M, Alegre-Martín J, Lobo B, González-Castro AM, Santos J, Domingo JC, Jurek J, Castro-Marrero J
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Claims (7)
People with inflammatory bowel disease often have a more permeable intestinal barrier, and this same condition is commonly observed in other chronic diseases.
In people with inflammatory bowel diseases, the lining of the intestines becomes more porous, and this change is linked to several other long-term health conditions.
In people with fibromyalgia, higher levels of a specific inflammatory protein in the blood are linked to less severe autonomic nervous system symptoms.
Blood levels of four specific biological molecules—zonulin-1, anti-beta-lactoglobulin IgG antibodies, lipopolysaccharides, and soluble CD14—can be used to tell apart people with fibromyalgia or chronic fatigue syndrome from those without these conditions, with a high level of accuracy based on statistical measures.
People with myalgic encephalomyelitis/chronic fatigue syndrome have higher levels of certain blood markers related to intestinal barrier function and immune response than healthy individuals, and higher levels of one of these markers, zonulin-1, are linked to the severity of autonomic nervous system symptoms.