The Study
Effects of a polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study
This study is like a fair test where half the people got a special berry pill and half got a fake pill, and no one knew who got what. It found that the berry pill might help people think a little faster and remember where things are better, but it didn't help them remember stories or names better. So we can't say it 'fixes memory'—just that it might help with a few thinking skills.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
Scientists tested if a special grape and blueberry supplement helps older people with mild memory problems think better.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 578 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Faster thinking and better visual learning may help with daily tasks like driving or following directions, but not with remembering names or events.
- 2People who took the supplement got 9.5% faster at processing info, learned visual tasks better, and felt better about their planning skills — but their memory didn't improve more than those who took a sugar pill.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Frontiers in Psychology
Year
2023
Authors
A. Lopresti, Stephen J. Smith, Camille Pouchieu, Line Pourtau, D. Gaudout, V. Pallet, P. Drummond
Related Content
Claims (6)
People who eat diets high in polyphenols have better cognitive function and a lower incidence of cognitive decline with aging.
In adults aged 60–80 with mild cognitive impairment, taking 300 mg of a standardized grape and blueberry extract daily for 24 weeks results in a 9.53% increase in the speed of information processing compared to taking a placebo.
Taking 300 mg of Memophenol™ daily for 24 weeks does not change episodic memory in adults aged 60–80 with mild cognitive impairment compared to a placebo.
Adults aged 60–80 with mild cognitive impairment who take 300 mg of Memophenol™ daily for 24 weeks show a measurable increase in their ability to learn and remember visual-spatial information compared to those taking a placebo.
Taking 300 mg of Memophenol™ daily for 24 weeks leads to a 5.90% improvement in executive function scores on the BRIEF-A questionnaire in adults aged 60–80 with mild cognitive impairment, with the largest change seen in metacognition.
Taking 300 mg of Memophenol™ every day for 24 weeks does not change working memory, attention accuracy, or quality of life in adults aged 60–80 with mild cognitive impairment.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.