The Study
Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction.
This study looked at lots of smaller experiments where people took hyaluronic acid pills and found that, on average, their skin seemed a bit more hydrated and smoother. But it didn't prove the pills caused it—just that they were linked to better skin in those studies.
Analysis score
Maximum 100 for a systematic review with meta-analysis.
Where the score came from
People took HA pills for a few months to see if it helped their skin look better.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 539 / 100
Quality score
The highest quality evidence. Systematic reviews and meta-analyses that pool randomized controlled trials, giving the most reliable summary of experimental evidence.
Key takeaways
Summary
Based on the study abstract and findings.
- 1These changes are noticeable enough to matter for someone wanting smoother, plumper skin without injections.
- 2Skin got 15–25% more hydrated, 10–20% more elastic, and wrinkles got 5–15% shallower.
- 3Firmness, wrinkle volume, and water loss didn't change much.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Journal of drugs in dermatology : JDD
Year
2025
Authors
Pouya Amin, Ali Sarabi, Sarah Choe, Sacha Scott, Susie Suh, N. Mesinkovska
Related Content
Claims (4)
Taking 200 mg of hyaluronic acid by mouth every day increases skin hydration and decreases wrinkle depth in humans.
There are only seven small studies on oral hyaluronic acid and skin health, and their methods are unclear, so it is not possible to be confident about how much benefit it provides.
Taking 120 to 200 mg of oral hyaluronic acid daily for 8 to 12 weeks increases skin hydration by 15-25%, improves skin elasticity by 10-20%, and reduces wrinkle depth by 5-15% in healthy adults aged 30-60.
Taking hyaluronic acid by mouth does not significantly improve skin firmness, reduce wrinkles, or change water loss through the skin in healthy adults between 30 and 60 years old.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.