A plant extract from Bombax ceiba calyces lowers the spike in blood sugar that occurs after consuming sugar in rats.
Mechanism
Synthesis from 1 study
The plant extract helps lower blood sugar after eating sugar by making the pancreas release more insulin and helping muscles and the liver soak up more sugar from the blood. This happens because natural chemicals in the plant interact with cells to improve how insulin works.
Most probable mechanism
Natural compounds in the plant extract enter the bloodstream and tell the pancreas to release more insulin, while also helping muscle and liver cells take in more sugar from the blood, which lowers the spike in blood sugar after eating sugar.
Bioactive phytometabolites (e.g., flavonoids and phenolic acids) are absorbed from the gastrointestinal tract into systemic circulation
These compounds bind to receptors on pancreatic beta cells, triggering calcium influx and stimulating insulin secretion
Insulin signaling pathways (IRS-1/PI3K/Akt) are activated in skeletal muscle and liver tissues
GLUT4 glucose transporters move to the cell membrane in insulin-sensitive tissues, increasing glucose uptake from the blood
Evidence from Studies
Supporting (1)
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