A specific red light treatment made cartilage cells in a dish produce more of a key structural protein that helps keep joints healthy
Scientific Claim
Near-infrared light at 850 nm with 4 mW/cm² power density, pulsed mode, applied every other day for 120 seconds, significantly increased aggrecan expression in cultured human chondrocytes from a 46-year-old female donor
Original Statement
“ACAN expression (Fig. 5 B) was also significantly elevated following PBM (p < 0.001). Stimulating chondrocytes with 4 mW/cm² at 850 nm (pulsed, every other day) did not alter ACAN production”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The study directly measured aggrecan expression with no statistical significance for this specific parameter, so 'did not alter' is appropriate.
More Accurate Statement
“Near-infrared light at 850 nm with 4 mW/cm² power density, pulsed mode, applied every other day for 120 seconds, did not significantly alter aggrecan expression in cultured human chondrocytes from a 46-year-old female donor”
Evidence from Studies
Supporting (1)
Near-infrared photobiomodulation stimulates viability and cartilage matrix synthesis in human chondrocytes