Phytic acid, a compound found in certain plant foods, is associated with maintaining the integrity of the intestinal lining and reducing inflammatory responses in the gut. Without it, the intestinal...
Mechanism
Synthesis from 2 studies
Phytic acid keeps your gut lining sealed by stopping enzymes that break down the connections between cells and by turning off signals that cause inflammation. Without it, those enzymes and signals run unchecked, causing leaks and swelling in the gut.
Most probable mechanism
When phytic acid is present, it helps keep the gut lining tight by turning off enzymes that break down the glue between gut cells and calming down inflammatory signals. Without it, those enzymes get activated, the glue breaks down, and the gut leaks, letting in harmful substances that trigger swelling and irritation.
Phytic acid binds directly to HDAC3 on chromatin, enabling recruitment of the NCoR1/2 corepressor complex via its DAD domain.
Activated HDAC3 removes acetyl groups from histone H4K16 at promoters of matrix metalloproteinase (MMP) genes.
Deacetylation of H4K16 suppresses transcription of MMPs, preventing degradation of tight junction proteins such as ZO-1, occludin, and claudin-2.
Phytic acid inhibits phosphorylation of AKT, reducing activation of the IKK complex and preventing degradation of IκBα.
Stabilized IκBα retains NF-κB p65 in the cytoplasm, blocking its nuclear translocation and transcriptional activity.
Suppressed NF-κB activity reduces expression of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α.
Preserved tight junction proteins and reduced inflammation maintain epithelial barrier integrity and prevent bacterial translocation.
Evidence from Studies
Supporting (2)
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Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function
The improved effect and its mechanism of phytic acid on DSS-induced UC mice.
Contradicting (0)
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