Can a natural compound in grains help calm a sore gut?
The improved effect and its mechanism of phytic acid on DSS-induced UC mice.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a natural substance found in grains (phytic acid) to mice with inflamed intestines and saw their guts got better. They also tested it on human gut cells in a dish and saw the same calming effect.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 58 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a natural substance found in grains (phytic acid) to mice with inflamed intestines and saw their guts got better. They also tested it on human gut cells in a dish and saw the same calming effect.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 58 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
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Claims (6)
Phytic acid, a compound found in certain plant foods, is associated with maintaining the integrity of the intestinal lining and reducing inflammatory responses in the gut. Without it, the intestinal barrier may become less effective and inflammation may increase.
In laboratory-grown human gut cells exposed to a bacterial toxin, phytic acid lowers the production of inflammatory molecules and helps maintain the proteins that seal the gaps between cells, supporting the barrier function of the gut lining.
In mice with chemically induced colitis, phytic acid supplementation is linked to lower severity of symptoms, such as less weight loss and shorter colon shortening.
In mice with a form of intestinal inflammation, phytic acid supplementation is linked to less weight loss, longer colon length, lower levels of certain inflammatory molecules, and better preservation of proteins that maintain the intestinal barrier.
Phytic acid reduces the activity of specific cellular signaling pathways involved in inflammation in mouse models of intestinal inflammation and in human intestinal cells exposed to bacterial triggers.