In laboratory-grown human gut cells exposed to a bacterial toxin, phytic acid lowers the production of inflammatory molecules and helps maintain the proteins that seal the gaps between cells,...
Mechanism
Synthesis from 1 study
When gut cells sense a bacterial toxin, they usually start leaking and swelling with inflammation. Phytic acid stops this by blocking a key internal alarm system, keeping the cells sealed and calm. This keeps the gut lining intact and prevents harmful substances from slipping through.
Most probable mechanism
When gut cells are exposed to a bacterial toxin, they normally start producing inflammatory signals and break down their protective seals. Phytic acid blocks a key internal signal that triggers this response, keeping the inflammatory signals low and the seals between cells intact, so the gut lining stays strong and doesn't leak.
Phytic acid enters intestinal epithelial cells and interferes with the activation of the AKT kinase
Inhibition of AKT prevents activation of the IKK complex, which normally tags the inhibitor protein IκBα for destruction
Stable IκBα retains the transcription factor NF-κB p65 in the cytoplasm, preventing its movement into the nucleus
Without nuclear NF-κB p65, the genes for pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) are not turned on
Reduced inflammatory signaling preserves the expression of tight junction proteins (occludin, claudin-3, ZO-1) and mucin-2
Intact tight junctions and mucus layer maintain the physical barrier between the gut lumen and underlying tissue
Evidence from Studies
Supporting (1)
Community contributions welcome
The improved effect and its mechanism of phytic acid on DSS-induced UC mice.
Contradicting (0)
Community contributions welcome
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