Among adults with obesity, those who burn more calories at rest before losing weight tend to regain more weight over the following year, with each additional 100 calories burned per day linked to...
Mechanism
Synthesis from 1 study
People with obesity who burn more calories while resting before dieting end up hungrier after losing weight, so they eat more — and their bodies use that extra food to rebuild muscle faster than fat, causing them to regain more weight (10.1038/s41366-021-00748-y).
Most probable mechanism
People with obesity who burn more calories at rest before dieting end up feeling hungrier afterward, so they eat more, and their bodies use that extra food to rebuild muscle and fat faster, causing them to regain more weight — this is shown in the study with DOI 10.1038/s41366-021-00748-y.
Higher adjusted 24-hour energy expenditure during sedentary, eucaloric conditions reflects elevated basal metabolic rate and/or digestive efficiency, creating a persistent energy demand signal relative to body size.
This elevated energy demand activates central appetite-regulating pathways, increasing orexigenic drive and reducing satiety signaling, leading to hyperphagia during free-living conditions after caloric restriction.
Excess energy intake from hyperphagia is preferentially stored as fat-free mass and fat mass, with fat-free mass restoration being the dominant contributor to total weight regain.
Evidence from Studies
Supporting (1)
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