People with obesity who burn more calories at rest before losing weight tend to regain more fat and muscle mass after one year, with each extra 100 calories burned per day linked to about 2.9...
Mechanism
Synthesis from 1 study
People who naturally burn more calories while resting before losing weight end up feeling hungrier after the diet, so they eat more than they need — and their bodies use that extra food to rebuild both muscle and fat, as shown in the study with DOI 10.1038/s41366-021-00748-y.
Most probable mechanism
People with obesity who burn more calories at rest before dieting end up feeling hungrier afterward, so they eat more than needed, and their bodies use that extra food to rebuild both muscle and fat tissue they lost during weight loss — this is shown in the study with DOI 10.1038/s41366-021-00748-y.
Higher 24-hour energy expenditure during sedentary, eucaloric conditions reflects elevated basal metabolic rate and/or digestive efficiency, creating a persistent energy demand that exceeds intake under controlled conditions.
This sustained energy demand activates central appetite-regulating pathways, increasing orexigenic signaling and reducing satiety sensitivity during post-diet free-living conditions.
Increased orexigenic drive leads to hyperphagia, resulting in excess energy intake that exceeds maintenance needs after caloric restriction ends.
The excess energy is preferentially stored as both fat mass and fat-free mass due to physiological restoration of lean tissue and adipose depots depleted during weight loss.
Evidence from Studies
Supporting (1)
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