After four weeks of mirabegron, healthy women had 35% more adiponectin, a hormone that helps regulate blood sugar. This finding is from the abstract summary - full study details were not available
Scientific Claim
In healthy women receiving 100 mg mirabegron daily for four weeks, adiponectin levels increased by 35% at the end of the study.
Original Statement
“Adiponectin, a WAT-derived hormone that has anti-diabetic and anti-inflammatory capabilities, increased with acute treatment and was 35% higher at study completion.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The study is an open-label, single-arm trial without a control group, so it can only show association, not causation. The claim uses 'increased' which implies causation, but the design only supports association.
More Accurate Statement
“In healthy women receiving 100 mg mirabegron daily for four weeks, adiponectin levels were associated with a 35% increase at the end of the study.”
Evidence from Studies
Supporting (1)
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.