Taking mirabegron for four weeks made healthy women burn more calories at rest without losing weight. This finding is from the abstract summary - full study details were not available
Scientific Claim
In healthy women with a mean age of 27.5 years and BMI of 25.4 kg/m², four weeks of 100 mg daily mirabegron treatment resulted in higher whole-body resting energy expenditure without changes in body weight or composition.
Original Statement
“Whole-body REE was higher, without changes in body weight or composition.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The study is an open-label, single-arm trial without a control group, so it can only show association, not causation. The claim uses 'resulted in higher' which implies causation, but the design only supports association.
More Accurate Statement
“In healthy women with a mean age of 27.5 years and BMI of 25.4 kg/m², four weeks of 100 mg daily mirabegron treatment was associated with higher whole-body resting energy expenditure without changes in body weight or composition.”
Evidence from Studies
Supporting (1)
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.