Healthy women who took mirabegron pills for four weeks had more active brown fat, which helps burn calories. This finding is from the abstract summary - full study details were not available
Scientific Claim
In healthy women with a mean age of 27.5 years and BMI of 25.4 kg/m², four weeks of 100 mg daily mirabegron treatment increased brown adipose tissue metabolic activity as measured by [18F]-FDG PET/CT.
Original Statement
“Chronic mirabegron therapy increased BAT metabolic activity.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The study is an open-label, single-arm trial without a control group, so it can only show association, not causation. The claim uses 'increased' which implies causation, but the design only supports association.
More Accurate Statement
“In healthy women with a mean age of 27.5 years and BMI of 25.4 kg/m², four weeks of 100 mg daily mirabegron treatment was associated with increased brown adipose tissue metabolic activity as measured by [18F]-FDG PET/CT.”
Evidence from Studies
Supporting (1)
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.