After losing weight, women who are postmenopausal and obese show simultaneous increases in two gut hormones, GLP-1 and GIP, after eating. These hormonal changes may help reduce hunger and improve...

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Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women

Randomized Controlled Trial

Human

2019 Jun 1

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No contradicting evidence found

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Source Study

Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women

Score: 60

DOI: 10.1530/EJE-19-0082

Similar Assertions

When postmenopausal women with obesity lose 10-11% of their body weight over two years, their bodies produce more glucagon-like peptide-1 after eating, a hormone that helps signal fullness.

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Losing weight by turning on a specific brain and gut signal (GLP-1) can help improve health problems linked to obesity, like high blood sugar or high blood pressure.

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In healthy women who are obese and past menopause, losing weight is linked to higher glucagon levels during fasting, less suppression of glucagon after eating, and higher ketone levels, indicating a metabolic shift toward breaking down stored energy.

71%

After 24 months on a Paleolithic diet, healthy postmenopausal women who are obese show a 23% higher rise in the hormone GIP after meals compared to those on a different diet, even when weight loss is accounted for.

71%