After two weeks of intermittent fasting, certain muscle signaling molecules changed—GSK became more active and mTOR less active—but these didn’t translate into changes in how the body used sugar or muscle protein overall.

37

Pro

0

Against

Evidence from Studies

Supporting (1)

37

Community contributions welcome

37

Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism.

Cross-Sectional Study

Human

2009 Nov

The study found that skipping meals for two weeks changed certain muscle signals (GSK and mTOR) but didn’t affect how the body uses sugar or protein overall — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism.

Score: 37

DOI: 10.3945/ajcn.2008.27327

Similar Assertions

Skipping meals intermittently for two weeks didn’t change how the body uses sugar, fat, or muscle protein in healthy, lean people—even when their insulin levels were raised.

37

0

78%

When healthy adults don’t eat for 3.5 days, their bodies start breaking down fat for energy—even though the usual fat-burning hormones and blood sugar levels stay pretty much the same.

45

0

72%