Why fasting might make you gain weight
Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People who ate only during certain hours for two weeks didn't burn more sugar, fat, or protein, but their bodies burned fewer calories at rest.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People who ate only during certain hours for two weeks didn't burn more sugar, fat, or protein, but their bodies burned fewer calories at rest.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 537 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans M, Jonkers-Schuitema CF, Fliers E, Sauerwein HP, Aerts JM, Serlie MJ
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Claims (3)
After two weeks of intermittent fasting, certain muscle signaling molecules changed—GSK became more active and mTOR less active—but these didn’t translate into changes in how the body used sugar or muscle protein overall.
Skipping meals intermittently for two weeks didn’t change how the body uses sugar, fat, or muscle protein in healthy, lean people—even when their insulin levels were raised.
After two weeks of skipping meals intermittently, the body burns fewer calories at rest—which could make you gain weight if you keep eating the same amount.