Blocking eosinophil adhesion molecules with RGDS peptide reduces collagen and fibronectin gene activity in airway muscle cells to levels seen with healthy eosinophils.

Scientific Claim

Suppression of eosinophil integrins using RGDS peptide is associated with reduced COL1A1 and fibronectin gene expression in airway smooth muscle cells to levels similar to those seen with healthy eosinophils (p < 0.05).

Original Statement

“Integrins’ suppression only affected asthmatic eosinophils—before and 24 h after bronchial allergen challenge on all four—TGF-β1, WNT-5A, COL1A1, and FN-expression in ASM cells after incubation with eosinophils. Gene expression was significantly downregulated before (accordingly COL1A1 3.15 ± 0.36 vs. 1.78 ± 0.21 folds over control ASM cells, p < 0.05; FN 2.75 ± 0.59 vs. 1.32 ± 0.08 folds over control ASM cells, p < 0.05)”

From study:In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and in vitro, so causal language is inappropriate. 'Associated with' correctly reflects the associative evidence.

Evidence from Studies

Supporting (1)

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Cross-Sectional Study

Human

2020 Mar 6

Contradicting (0)

No contradicting evidence found

Source Study

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Score: 38

DOI: 10.3390/ijms21051837

Similar Assertions

Airway muscle cells grown with allergen-activated asthma eosinophils produce nearly 5 times more fibronectin gene activity than when grown with healthy eosinophils.

73%

Airway muscle cells grown with allergen-activated asthma eosinophils produce over 5 times more collagen I gene activity than when grown with healthy eosinophils.

71%