Airway muscle cells grown with allergen-activated asthma eosinophils produce over 5 times more collagen I gene activity than when grown with healthy eosinophils.

Scientific Claim

Airway smooth muscle cells co-cultured with allergen-activated eosinophils from allergic asthma patients are associated with a 5.70-fold increase in COL1A1 gene expression compared to co-culture with healthy eosinophils (p < 0.05).

Original Statement

“allergen-activated asthmatic eosinophils significantly increased COL1A1 and FN expression compared to healthy eosinophils, accordingly 5.70 ± 0.86 vs. 2.39 ± 0.37 folds over control ASM cells, p < 0.05”

From study:In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and in vitro, so causal language is inappropriate. 'Associated with' correctly reflects the associative evidence.

Evidence from Studies

Supporting (1)

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Cross-Sectional Study

Human

2020 Mar 6

Contradicting (0)

No contradicting evidence found

Source Study

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Score: 38

DOI: 10.3390/ijms21051837

Similar Assertions

Airway muscle cells grown with allergen-activated asthma eosinophils produce nearly 5 times more fibronectin gene activity than when grown with healthy eosinophils.

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Whether asthma eosinophils are activated by allergens or not, they don't change the activity of the WNT-5A gene in airway muscle cells.

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When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about twice as much TGF-β1 protein as when grown with healthy eosinophils.

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When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about 50% more TGF-β1 protein than when grown with non-activated eosinophils.

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When eosinophils from asthma patients are exposed to allergens, they produce about 1.58 times more TGF-β1 protein compared to before exposure, which may contribute to inflammation.

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