When eosinophils from asthma patients are exposed to allergens, they produce about 1.58 times more TGF-β1 protein compared to before exposure, which may contribute to inflammation.

Scientific Claim

Allergen-activated eosinophils from allergic asthma patients are associated with a 1.58-fold increase in TGF-β1 gene expression compared to non-activated eosinophils (p < 0.05).

Original Statement

“The gene expression was significantly higher 24 h after bronchial allergen challenge for 1.58 ± 0.18 folds over non-activated asthmatic eosinophils, p < 0.05 (Figure 1)”

From study:In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and in vitro, so causal language is inappropriate. Using 'associated with' correctly reflects the associative evidence.

Evidence from Studies

Supporting (1)

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Cross-Sectional Study

Human

2020 Mar 6

Contradicting (0)

No contradicting evidence found

Source Study

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Score: 38

DOI: 10.3390/ijms21051837

Similar Assertions

Eosinophils from asthma patients already produce more TGF-β1 protein than healthy people even before allergen exposure.

94%

When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about twice as much TGF-β1 protein as when grown with healthy eosinophils.

84%

When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about 50% more TGF-β1 protein than when grown with non-activated eosinophils.

80%

Airway muscle cells grown with allergen-activated asthma eosinophils produce over 5 times more collagen I gene activity than when grown with healthy eosinophils.

77%

In asthma patients, the number of eosinophils in blood increases from 0.34 to 0.52 billion per liter within 24 hours after allergen exposure.

75%