When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about twice as much TGF-β1 protein as when grown with healthy eosinophils.

Scientific Claim

Co-culture of airway smooth muscle cells with allergen-activated eosinophils from allergic asthma patients is associated with a median TGF-β1 concentration of 1643 pg/mL in culture supernatants, compared to 725 pg/mL with healthy eosinophils (p < 0.05).

Original Statement

“The same tendency was 24 h after challenge: allergen-activated eosinophils significantly increased the concentration of TGF-β1 in culture supernatants compared to healthy eosinophils, accordingly 1643 (1224–3160) pg/mL vs. 725 (606–1673) pg/mL, p < 0.05.”

From study:In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design is observational and in vitro, so causal language is inappropriate. 'Associated with' accurately reflects the associative evidence.

Evidence from Studies

Supporting (1)

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Cross-Sectional Study

Human

2020 Mar 6

Contradicting (0)

No contradicting evidence found

Source Study

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Score: 38

DOI: 10.3390/ijms21051837

Similar Assertions

When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about 50% more TGF-β1 protein than when grown with non-activated eosinophils.

96%

Airway muscle cells grown with allergen-activated asthma eosinophils produce over 5 times more collagen I gene activity than when grown with healthy eosinophils.

88%

Airway muscle cells grown with allergen-activated asthma eosinophils produce nearly 5 times more fibronectin gene activity than when grown with healthy eosinophils.

85%

When eosinophils from asthma patients are exposed to allergens, they produce about 1.58 times more TGF-β1 protein compared to before exposure, which may contribute to inflammation.

84%

Whether asthma eosinophils are activated by allergens or not, they don't change the activity of the WNT-5A gene in airway muscle cells.

82%