How allergy triggers cause lung scarring in asthma
In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When people with asthma breathe in allergens, their white blood cells (eosinophils) get activated and send signals that make lung muscles produce more scar-like proteins. Blocking these signals with a special peptide stops the scarring.
Surprising Findings
WNT-5A gene expression didn't change despite increased collagen and fibronectin
Previous research suggested WNT-5A was a key regulator of ECM production in asthma, but this study found no change in WNT-5A even when collagen increased 5.7x
Practical Takeaways
Support research into integrin-blocking therapies for asthma
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When people with asthma breathe in allergens, their white blood cells (eosinophils) get activated and send signals that make lung muscles produce more scar-like proteins. Blocking these signals with a special peptide stops the scarring.
Surprising Findings
WNT-5A gene expression didn't change despite increased collagen and fibronectin
Previous research suggested WNT-5A was a key regulator of ECM production in asthma, but this study found no change in WNT-5A even when collagen increased 5.7x
Practical Takeaways
Support research into integrin-blocking therapies for asthma
Publication
Journal
International Journal of Molecular Sciences
Year
2020
Authors
I. Janulaityte, Andrius Januškevičius, V. Kalinauskaite-Zukauske, Ieva Bajoriūnienė, K. Malakauskas
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Claims (10)
Collagen peptides function as signaling molecules that activate gene expression pathways responsible for collagen synthesis and tissue remodeling.
When eosinophils from asthma patients are exposed to allergens, they produce about 1.58 times more TGF-β1 protein compared to before exposure, which may contribute to inflammation.
When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about twice as much TGF-β1 protein as when grown with healthy eosinophils.
Airway muscle cells grown with allergen-activated asthma eosinophils produce over 5 times more collagen I gene activity than when grown with healthy eosinophils.
Airway muscle cells grown with allergen-activated asthma eosinophils produce nearly 5 times more fibronectin gene activity than when grown with healthy eosinophils.