Airway muscle cells grown with allergen-activated asthma eosinophils produce nearly 5 times more fibronectin gene activity than when grown with healthy eosinophils.

Scientific Claim

Airway smooth muscle cells co-cultured with allergen-activated eosinophils from allergic asthma patients are associated with a 4.96-fold increase in fibronectin gene expression compared to co-culture with healthy eosinophils (p < 0.01).

Original Statement

“allergen-activated asthmatic eosinophils significantly increased COL1A1 and FN expression compared to healthy eosinophils, accordingly 4.96 ± 0.76 vs. 1.73 ± 0.23 folds over control ASM cells, p < 0.01”

From study:In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design is observational and in vitro, so causal language is inappropriate. 'Associated with' accurately reflects the associative evidence.

Evidence from Studies

Supporting (1)

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Cross-Sectional Study

Human

2020 Mar 6

Contradicting (0)

No contradicting evidence found

Source Study

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Score: 38

DOI: 10.3390/ijms21051837

Similar Assertions

Airway muscle cells grown with allergen-activated asthma eosinophils produce over 5 times more collagen I gene activity than when grown with healthy eosinophils.

92%

When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about twice as much TGF-β1 protein as when grown with healthy eosinophils.

85%

Whether asthma eosinophils are activated by allergens or not, they don't change the activity of the WNT-5A gene in airway muscle cells.

84%

When airway muscle cells are grown with allergen-activated asthma eosinophils, the fluid around them has about 50% more TGF-β1 protein than when grown with non-activated eosinophils.

84%

When eosinophils from asthma patients are exposed to allergens, they produce about 1.58 times more TGF-β1 protein compared to before exposure, which may contribute to inflammation.

73%