In asthma patients, the number of eosinophils in blood increases from 0.34 to 0.52 billion per liter within 24 hours after allergen exposure.

Scientific Claim

Allergic asthma patients show a 0.52 ×10^9/L blood eosinophil count 24 hours after allergen challenge compared to baseline 0.34 ×10^9/L (p < 0.05).

Original Statement

“Blood eosinophil count, ×109/L 0.34 ± 0.11 * # 0.52 ± 0.30 # 0.15 ± 0.06 0.16 ± 0.04”

From study:In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and in vitro, so causal language is inappropriate. 'Show' accurately reflects the descriptive association.

Evidence from Studies

Supporting (1)

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Cross-Sectional Study

Human

2020 Mar 6

Contradicting (0)

No contradicting evidence found

Source Study

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Score: 38

DOI: 10.3390/ijms21051837

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When eosinophils from asthma patients are exposed to allergens, they produce about 1.58 times more TGF-β1 protein compared to before exposure, which may contribute to inflammation.

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