In asthma patients, the number of eosinophils in sputum nearly doubles from 5.5% to 13.3% within 24 hours after allergen exposure.

Scientific Claim

Allergic asthma patients exhibit a 13.3% sputum eosinophil count 24 hours after allergen challenge compared to baseline 5.5% (p < 0.05).

Original Statement

“Sputum eosinophil count, % (AA n = 9, HS n = 7) Baseline 5.5 ± 5.4 * # 13.3 ± 12.87 # 0.1 ± 0.2 0.5 ± 0.4”

From study:In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and in vitro, so causal language is inappropriate. 'Exhibit' accurately reflects the descriptive association.

Evidence from Studies

Supporting (1)

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Cross-Sectional Study

Human

2020 Mar 6

Contradicting (0)

No contradicting evidence found

Source Study

In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma

Score: 38

DOI: 10.3390/ijms21051837

Similar Assertions

In asthma patients, the number of eosinophils in blood increases from 0.34 to 0.52 billion per liter within 24 hours after allergen exposure.

91%

When eosinophils from asthma patients are exposed to allergens, they produce about 1.58 times more TGF-β1 protein compared to before exposure, which may contribute to inflammation.

74%